Methylation-related metabolic effects of D4 dopamine receptor expression and activation
نویسندگان
چکیده
منابع مشابه
The Dopamine D4 Receptor
The observation that receptors which mediate their signals through heterotrimeric guanosine triphosphate (GTP)-binding proteins (Gproteins) share a considerable amount of sequence similarity has resulted in the rapid molecular characterization of this receptor superfamily. Moreover, it became clear that several receptor families consisted of more receptor subtypes than originally anticipated fr...
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OBJECTIVE The goal of our study was to investigate whether DRD4 gene DNA methylation played an important role in the susceptibility of Han Chinese SCZ. METHODS Using the bisulphite pyrosequencing technology, DNA methylation levels of 6 CpG dinucleotides in DRD4 CpG island were measured among 30 paranoid SCZ patients, 30 undifferentiated SCZ patients, and 30 age- and gender-matched healthy con...
متن کاملActivation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
The dopaminergic and renin-angiotensin systems interact to regulate blood pressure. Disruption of the D4 dopamine receptor gene in mice produces hypertension that is associated with increased renal angiotensin type 1 (AT1) receptor expression. We hypothesize that the D4 receptor can inhibit AT1 receptor expression and function in renal proximal tubule cells from Wistar-Kyoto (WKY) rats, but the...
متن کاملExpression of a Novel D4 Dopamine Receptor in the Lamprey Brain. Evolutionary Considerations about Dopamine Receptors
Numerous data reported in lampreys, which belong to the phylogenetically oldest branch of vertebrates, show that the dopaminergic system was already well developed at the dawn of vertebrate evolution. The expression of dopamine in the lamprey brain is well conserved when compared to other vertebrates, and this is also true for the D2 receptor. Additionally, the key role of dopamine in the stria...
متن کاملGenetic variants of dopamine receptor D4 and psychopathology.
There is much evidence to indicate that the dopamine receptor D4 (DRD4) gene is involved in psychiatric disorders. We investigated the correlation between DRD4 gene polymorphism and the psychopathology of major psychoses, independently of diagnoses. Some 461 inpatients affected by major psychoses were assessed by the Operational Criteria checklist for psychotic illness and typed for DRD4 varian...
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ژورنال
عنوان ژورنال: Translational Psychiatry
سال: 2019
ISSN: 2158-3188
DOI: 10.1038/s41398-019-0630-3